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when lipid peroxides accumulate excessively, polyunsaturated fatty acids in hepatocytes are synthesized into easily oxidizable phospholipids under enzymatic action, which then undergo peroxidation catalyzed by enzymes, disrupting cell membrane structure and ultimately leading to hepatocyte necrosis and liver failure [58]

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Another extensive research paper looked at whether the timing of acetaminophen exposure was relevant

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DOI: 10.1210/jc.2005-1536 Falutz, J., et al