Sofosbuvir-specific clinically relevant RAS were L159F, S282T/R, L320I/F/V and V321A, depending on genotype/subtype, and dasabuvir-specific clinically relevant RAS were L314H and C316H/N/Y/W (only for GT1)
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Advise patients of the characteristic symptoms of heart failure and to immediately report such symptoms
The powder form can typically withstand room temperature for days to weeks without significant degradation, but once reconstituted, refrigeration is mandatory
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