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The glucagon component appears to turn up energy expenditure, which is the mechanistic reason its weight-loss numbers ran higher than single and dual agonists in clinical testing

Proc Natl Acad Sci U S A 105:1356813573 Shibata T, Kokubu A, Saito S, Narisawa-Saito M, Sasaki H, Aoyagi K, Yoshimatsu Y, Tachimori Y, Kushima R, Kiyono T, Yamamoto M (2011) NRF2 mutation confers malignant potential and resistance to chemoradiation therapy in advanced esophageal squamous cancer

Research has shown that sulfite can induce mast cell degranulation, a process where mast cells release their contents, including histamine