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The drug's multireceptor approach addresses several metabolic processes, contributing to: Improved cardiovascular health: Retatrutide has been shown to lower blood pressure and improve cholesterol levels, reducing the risk of heart disease in individuals with obesity

doi: 10.1016/j.canlet.2014.04.001 72 KoltaiTFliegelL

The primary endpoint might be a reduction in 1-year heart failure hospitalization rates or improvement in left ventricular ejection fraction, with secondary endpoints including quality-of-life scores and biomarkers

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While injection site reactions occur in approximately 3.4% of patients in clinical trials, most cases are mild and resolve spontaneously