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GLP1 is a gut-derived polypeptide released from the intestinal L cells, capable of stimulating glucose-dependent insulin secretion and inhibiting food intake by acting on the pancreas and brain, respectively

Topical peptide, supplement and injection are different questions Search results often mix Can I use a peptide serum? with Can I take peptides? A cosmetic peptide on intact skin creates a different exposure from swallowing a supplement or injecting a compound

Vegans and vegetarians may have lower baseline levels due to reduced dietary intake, though clinical deficiency in otherwise healthy individuals remains uncommon

Patients with renal or hepatic impairment may be at higher risk of hypoglycemia [see Use in Specific Populations (8.6, 8.7)]

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