Tirzepatide is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2), and is not approved for use in children or adolescents under 18 years of age
Another clinical trial involving over 1,000 people with type 2 diabetes and a body mass index (BMI) of 27 or higher also showed that semaglutide was effective in promoting weight loss
For many people, this sweet spot is between 1.0 mg and 1.7 mg weekly
First-line management includes drinking 1.52 litres of fluids daily, using paracetamol (maximum 4 g daily) or ibuprofen (maximum 1.2 g daily for over-the-counter use) as appropriate, and resting in a quiet environment
While there are no known direct pharmacokinetic interactions between semaglutide and common migraine medications, semaglutide's effect on gastric emptying may delay the absorption and onset of oral medications, including pain relievers and triptans