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Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency

Proper solvent selection ensures that the peptide dissolves completely and maintains its intended function

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Therefore, when estimated assuming 50% additivity, the HRs were 0.73 (95% CI 0.620.87) for MACE, 0.53 (95% CI, 0.410.70) for HHF, and 0.51 (95% CI, 0.380.68) for CKD progression