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Excessive BDNF signaling has been associated with epileptiform activity in some research models

It is the only peptide in this class with human clinical data: the NERVARA trial (Phase 2, NCT02039687) studied its effect on diabetic neuropathy

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It is one of the very few animal peptides to contain a D-amino acid (D-alanine at position 2), an unusual feature that is generated post-translationally by enzymatic conversion of an L-alanine encoded in the gene [2]

Zuker also addresses how taste perception can change over time through repeated exposure and how the brain can modify taste preferences based on the body's nutritional needs, using examples like coffee consumption and salt cravings