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Senescent Cell Clearance Moderate Research Groundbreaking research demonstrates FOXO4-DRI's remarkable ability to selectively eliminate senescent cells through targeted disruption of the FOXO4-p53 survival mechanism, achieving significant senescent cell clearance rates in aged animal models without affecting healthy dividing cells

In EMPEROR-PRESERVED studying empagliflozin and in DELIVER studying dapagliflozin, there was a significant reduction in cardiovascular death and HF hospitalizations compared to placebo, driven mostly by reductions in HF hospitalizations

Proc Natl Acad Sci USA 111 , E12111220, doi:10.1073/pnas.1321347111 (2014)

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doi: 10.4061/2011/391762 116 VitariACDeakMCollinsBJMorriceNPrescottARPhelanAet al