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Second, the study was limited by the small sample size and the short treatment period (4 months)

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Anal Biochem 106 : 5562 Yang SR, Chida AS, Bauter MR, Shafiq N, Seweryniak K, Maggirwar SB, Kilty I, Rahman I 2006 Cigarette smoke induces proinflammatory cytokine release by activation of nf-kappab and posttranslational modifications of histone deacetylase in macrophages

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This translocation contributes to the de-repression of genes involved in mitochondrial function