however, it negatively affected the fetal weight, yet it was considered negligible due to liraglutides known effect of suppressing appetite ( As GLP-1 agonists have garnered attention for management of obesity due to their effect on reducing insulin sensitivity, they are now being considered a therapeutic option for the treatment of PCOS (polycystic ovarian syndrome), one of the most common causes of subfertility, diagnosed via Rotterdams criteria: oligomenorrhea, hyperandrogenism and polycystic ovaries (98)
Subjects were also not enrolled into the study if they had a previous medical history of any epilepsy, cancer (excluding non-malignant skin cancer), gastrointestinal, immunologic, or infectious diseases
IglayKHannachiHJoseph HowiePXuJLiXEngelSSet al
IGF-1R has been researched for its involvement in diverse types of cancer, such as prostate, breast, and lung cancer
But the serious adverse event profile remains remarkably thin compared to direct growth hormone administration