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10.3390/biomedicines8100428 18 El AlamS.PenaE.AguileraD.SiquesP.BritoJ
The adoption of a pro-inflammatory phenotype in microglia can be driven by various factors, including the presence of pro-inflammatory mediators, infiltration of peripheral immune cells, pathological deposits (such as tau aggregates), and viral proteins [e.g., proteins trans-activator of transcription (Tat)] [26, 27]
Treatment of 4.2 / mice with mitapivat significantly increased hematocrit (Hct) and Hb values, and Hb to RBC distribution width (RDW) ratio, a complementary RBC index for spherocytosis and dense RBCs, when compared with vehicle-treated animals (Figure 2A)