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AMG133 is a monoclonal antibody drug designed to block the glucose-dependent insulinotropic polypeptide (GIP) receptor and simultaneously bind to two modified GLP-1 peptide segments to activate the GLP-1 receptor

The B12 component addresses deficiency where present

Retatrutide is a triple agonist that activates GLP-1, GIP, and glucagon receptors

Hypothyroidism : Though thyroid nodules themselves dont directly cause hypothyroidism, if a large nodule requires removal, the resulting surgery may lead to hypothyroidism, which slows down the metabolism and can contribute to weight gain

Smoking is a preventable cause of oxidative damage in the body