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Several such trials and multiple systematic reviews through 2023 and 2024 show modest but statistically significant reductions in body weight, BMI, and fat mass with oral L-carnitine supplementation

Case in point: a 2013 review supported growth hormone therapy as a treatment for patients with cognitive impairment, theorizing that growth hormone may interact with receptors in the central nervous system associated with learning and memory.20 Another case in point: a 2018 review found that IGF-1 plays a major role in adult brain function and decreases with age, a decrease that seems to precede cognitive decline in the elderly.21 To tie this all together, we can point to a 2012 clinical trial directly examining the effects of tesamorelin on cognitive function

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Acknowledgements The authors thank the Department of Orthopedic Surgery and Traumatology of Saint-Antoine Hospital for providing human OA tissues

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