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take at night or reduce dose) Flushing or facial warmth Appetite suppression (desired in some cases) Fatigue or dizziness (rare) Less Common: Darkening of freckles or moles (especially in fair-skinned users) Hyperpigmentation of scars or birthmarks Spontaneous erections (especially in males at higher doses) Contraindications: History of melanoma or atypical nevi Active hormone-sensitive cancers Uncontrolled autoimmune flares without provider oversight Clinical Case Examples Case 1: Safe Tanning and Photosensitivity A 30-year-old female with light skin and lupus-associated photosensitivity followed the tanning protocol

- If the GLP-1 receptor agonist is being utilized for DMT2 management and holding a dose would impact their dosing schedule, consult the patients primary care physician or endocrinologist for bridging antidiabetic therapy to avoid hyperglycemia

The glossy or shiny look can result from tight compaction or slight melting during the lyophilization process before freeze-drying finishes

Effect of semaglutide on the pharmacokinetics of metformin, warfarin, atorvastatin and digoxin in healthy subjects