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Despite a substantial decrease in the muscle carnitine content (approximately 50%), there was no difference in spontaneous or running-wheel activities between control and cKOt mice (Supplemental Figure 7)

Give instructions for follow-up, such as drinking plenty of water and avoiding physically demanding activities

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A: While there isn't a universally fixed 'maximum,' researchers typically aim for the minimum effective 5-Amino-1MQ dosage to minimize off-target effects

10.1074/jbc.271.49.31372