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[4] [5] Patients considering these treatments should understand that they are not a substitute for lifestyle modification or evidence-based weight management strategies endorsed by NICE

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UK-licensed hydroxocobalamin injections are typically preservative-free single-use preparations, but it's always advisable to check the specific product's SmPC for excipient information if you suspect a sensitivity

Participants saw rapid initial loss through weeks 4 to 12, peak velocity between weeks 12 and 24 (roughly 1.8 pounds per week), gradual slowing between weeks 24 and 36, and a plateau or near-plateau by weeks 44 to 48