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A study published in Gastroenterology on March 27, 2024, indicates an increased risk of aspiration pneumonia associated with GLP-1RA use during endoscopic procedures involving propofol sedation targeting the upper gastrointestinal tract

Once removed from the fridge, pens can be kept at room temperature (below 86F/30C) for up to 21 days after which they must be discarded

The stock challenges have predominantly been seen owing to the price increase in August 2025, with many patients panic buying and stockpiling

Slower gastric emptying means slower intestinal transit, which means harder stools and less frequent bowel movements

No true generic versions are currently available in the United States due to patent protection held by manufacturer Novo Nordisk