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McGraw-Hill / Lange McCulloch DK (2017): Metformin in the treatment of adults with type 2 diabetes mellitus

Additionally, MTX-glu prevents the conversion of 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) to formaminoimidazole-4-carboxamide ribonucleotide (FAICAR) by inhibiting the key enzyme AICAR transformylase (ATIC) in the purines de novo synthesis pathway, leading to the accumulation of AICAR (Friedman and Cronstein 2019)

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Zhao YX, Chen SR, Su PP, et al