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360,361 To add up, by intravenously administering primed [U- 13 C]lactate (completely labeled with carbon-13 at three positions) and utilizing imaging mass spectrometry (IMS), Bartman et al

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Mechanistically, 16S rRNA sequencing and untargeted metabolomics revealed that dysbiosis-driven perturbation of the gutbacterialhost lipid axis elevates LD accumulation in hippocampal microglia, increases ceramide levels, and triggers maladaptive neuroimmune responses