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The inclusion of patients with severe asthma in registries will provide clinicians with information on long-term safety, and the longer-term follow-up of patients treated with biologics is crucial to verify the lack of subsequent occurrences

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These include glutathione, phytochelatins, and metallothioneins (Zhou et al., 2013

-TrCP is an adaptor protein for the Cul1-dependent SCF E3 and thereby promotes the ubiquitination and proteasomal degradation of Nrf2 independently of Keap1 (73)

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