retatrutide side effects clinical trial results Lilly orforglipron oral GLP-1 phase 3 weight loss Retatrutide—A Game Changer in Obesity

It activates two gut hormones at once

Weight re-gain since discontinuation was significantly associated with reinitiation

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Tsai WH, Sung FC, Chiu LT, Shih YH, Tsai MC, Wu SI

The GLP1-RAs vs sodium-glucose cotransporter-2 (SGLT-2) inhibitors cohort included new users of GLP-1 RAs ( n = 83,464 ) or SGLT-2 inhibitors ( n = 78,366 ), and the GLP1-RAs vs dipeptidyl peptidase-4 (DPP-4) inhibitors cohort included new users of GLP-1 RAs ( n = 108,322 ) or DPP-4 inhibitors ( n = 55,411 )