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Do I need to cycle off CJC-1295/Ipamorelin

Within the first several hours post ingestion: the patient is probably asymptomatic but may have some nausea and vomiting

Given the fairly short half-life of unbound IGF-1 in serum (i.e., 510 min), binding to an IGF binding protein (IGFBP-3 is the most prevalent) in serum or in ECM increases IGF-1 half-life to around 25 min (Allard and Duan, 2019), leading to the production of phosphatidylinositol 3,4,5-trisphosphate (PIP3) (O'Neill et al., 2015)

The resulting GH pulse is rapid and robust: peak plasma GH concentrations typically occur within 15 to 30 minutes of subcutaneous injection, with the pulse lasting approximately 60 to 90 minutes

Sermorelin is the simpler, gentler option one injection a day, closer to the bodys natural rhythm, historically FDA-approved pedigree