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It will be important for future studies to explore how substance use disorder severity affects the weight loss medications/substance use relationship something the researchers were not able to explore in the present study

Doing this can cause low blood sugar which can lead to some complications

Data are from the on-treatment observation period (during treatment with trial product [any dose of trial medication administered within the previous 49 days (that is, any period of temporary treatment interruption with trial product was excluded))

Efficacy Context: Clinical trials for combination therapies like naltrexone-bupropion or phentermine-topiramate typically show weight loss in the range of 510%, compared to 15% or more often seen with semaglutide in similar timeframes (Liu et al., 2024)

Dyspepsia : Indigestion and upper abdominal discomfort are frequently reported