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Elevation in NOX1 protein level was accompanied by a 2.8-fold increase in 4-HNE protein adduct content in alcohol-fed mice compared with controls (Fig

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Mechanistically, 16S rRNA sequencing and untargeted metabolomics revealed that dysbiosis-driven perturbation of the gutbacterialhost lipid axis elevates LD accumulation in hippocampal microglia, increases ceramide levels, and triggers maladaptive neuroimmune responses