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The major disadvantages of the aqueous liquid formulations are microbial contamination, chemical instability of the dissolved drug in aqueous conditions, presence of preservatives that may cause mucosal irritation, and short residence time in the nasal cavity due to mucociliary action [21]

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The optimal cutoff value for 5-oxoproline diagnosing acute ischemic stroke ( 7d) was 3.127 g/mL (sensitivity, 63.4 %