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Normally microglia are neuroprotective, cleaning out debris that may contribute to neurodegenerative diseases or damage from ischemic stroke, but in the case of TBI they can become overactivated and exacerbate neuroinflammation (with upregulated TNFa, IL-6, C3, NK-kB, CD68, etc), and vascular changes can result in headaches, neurovascular flow changes, impaired lymphatic flow, blood-brain barrier disruption, activation of pro-inflammatory pathways, neuronal death, hyperexcitability, and disrupted synaptic connections
Ladner and his team help patients achieve their aesthetic and wellness goals using advanced treatments like semaglutide injections and other proven weight loss solutions
The interests range from longevity research startups aimed at humans and even pets to developing a product for a French skin care company to advising a longevity investment fund
As a key regulator of oxidative stress, Nrf2 governs the expression of ARE-dependent genes (62,125)
