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Side effects, safety, and the boxed warning All GLP-1 agonists (and tirzepatide, a GIP/GLP-1 dual agonist) share a well-characterized profile: nausea, vomiting, diarrhea, constipation, abdominal pain, and headache are common, especially during the first 48 weeks and after each dose escalation

In the development of the GLP-1 receptor agonist, semaglutide, the strategy used to extend the drugs half-life was to promote covalent and non-covalent binding of semaglutide to albumin through the addition of a fatty-acid attachment on semaglutide

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However, GLP-1 agonists are unlikely to protect beta cells in type 1 diabetes, even though their other effects can be quite helpful

This product is not a substitute for a varied diet and a healthy lifestyle