Theres also a housekeeping component
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Increased superoxide production was observed in all layers of the vascular wall, namely the endothelium, media and adventitia, 14 and may also increase vasoconstrictor tone via stimulation of the expression of endothelin-1 in the smooth muscle and endothelial cell layer
Cell Physiol Biochem 53:865886 Juni RP, Kuster DWD, Goebel M, Helmes M, Musters RJP, van der Velden J, Koolwijk P, Paulus WJ, van Hinsbergh VWM (2019) Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function Is Impaired by Inflammation and Restored by Empagliflozin
TERAPIA INCRETINOMIMTICA: RESTAURANDO LA FUNCIN INCRETINA La necesidad de desarrollar nuevos frmacos antidiabticos con menos efectos adversos que los hipoglucemiantes orales comunes, como la sulfonilureas o tiazolidinedionas que incrementan el riesgo de hipoglicemia, aumento de peso o mortalidad cardiovascular, dio lugar a dos enfoques basados en el efecto incretina: los inhibidores de la DPP-4 (IDPP-4) y los agonistas del receptor del GLP-1 (GLP1-RA)
