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Tau and A are interacting triggers and drivers within a broader and more complex pathophysiological cascade of events, demanding multi-modal biomarker-guided targeted and mechanism driven, disease-modifying therapies

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For instance, typical characterization methods including Western blots or nanoparticle tracking analysis (NTA) offer limited resolution, measuring either the relative abundance of specific proteins or particle sizes alone

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Benedetti F, Serretti A, Colombo C, Barbini B, Lorenzi C, Campori E, et al