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Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1), and erythropoietin

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GLP-1 medicines are started low and stepped up deliberately: for Wegovy, 0.25 mg for weeks 1 to 4, then 0.5 mg, 1 mg, 1.7 mg, reaching the 2.4 mg maintenance dose at week 16

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Interruption of GLP1R signalling with exendin(9-39) alone increased the amplitude of glycaemic excursions