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The fact that there are more studies on the role of autophagy in ferroptosis compared with the regulation of autophagy by ferroptosis may be related to the easier observation of the responses of ferroptosis when regulating autophagy, the clearer regulatory pathways of autophagy on ferroptosis, and the greater clinical application potential of regulating ferroptosis through autophagy

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Under nutrient deprivation conditions, ULK1 is stimulated and Atg13, FIP200 and ULK1 itself are phosphorylated, resulting in the recruitment of other autophagy proteins for phagophore nucleation and assembly (28)