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Without timely treatment, NAFLD can progress to cirrhosis, hepatocellular carcinoma, and even death ( 2 Application of probiotic therapy in nonalcoholic fatty liver disease 2.1 NAFLD and probiotic therapy Recent studies have shown that regulation of gut microbiota can be a feasible strategy for preventing and treating NAFLD

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Particularly, metal chelation via catechol group linked with the free 3-OH group on the unconjugated dihydropyran heterocycle chain was elucidated to contribute to tyrosinase inhibition by (/+)-catechin against cyanidin-3- O -glucoside

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acnes and it also showed in vivo (on real people) that 5% SAP can strongly improve the inflammatory and non-inflammatory lesions of acne vulgaris