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It has been shown that Muller cells are activated secondary to retinal damage and have the ability to migrate and proliferate at the site of injury mainly due to the activity of bioactive sphingolipid compounds (Hamon et al

Moreover, NO seems to be the only mediator of cell proliferation arrest through the ERK1/2-p53 signaling pathway ( FIGURE 1 Next to this evidence, in our laboratory it has been demonstrated that GSH depletion modulates the peroxisome proliferator-activated receptor gamma, co-activator 1 alpha (PGC-1) expression and its downstream metabolic pathway in neuronal and skeletal muscle cells ( Figure 1 )

84 In mice models, pemvidutide lowered body weight and liver enzymes while promoting better blood glucose control, improved liver steatosis, inflammation and fibrosis superior to semaglutide

Cell Host microbe 31 , 528538 (2023)

Superoxide dismutase mimics: Chemistry, pharmacology, and therapeutic potential