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Olde Rikkert MG, Verhey FR, Sijben JW, Bouwman FH, Dautzenberg PL, Lansink M et al

determined that ferroptosis is a key mechanism underlying blood-retinal barrier damage in diabetic retinopathy, demonstrating that Flotillin-1 activates the Nrf2 pathway by enhancing its expression and promoting its nuclear translocation, thereby stimulating the SLC7A11/GPX4 pathway to inhibit lipid peroxidation and ferroptosis [168]

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To further explore the diversity characteristics of bacterial communities, the study implemented Principal Coordinates Analysis (PCoA) based on weighted UniFrac distances, supplemented by Analysis of Similarity (ANOSIM) to elucidate differences among communities