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Increased adipocyte O2 consumption triggers HIF-1, causing inflammation and insulin resistance in obesity

But again, this appears to be the exception rather than the rule

The FAQ states that tirzepatide is "generally prescribed for adults with a BMI of 30 or greater, or a BMI of 27 or greater with a weight-related condition like hypertension" and notes contraindications including personal or family history of medullary thyroid cancer, MEN 2, or pregnancy and breastfeeding

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