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older, non-selective agents are available for different routes of administration [i.e., oral (PO), intramuscular (IM), and intravenous (IV)] and continue to be investigated actively (Pereira and Goudet, 2019)

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Efficacy of high-intensity laser therapy in comparison with conventional physiotherapy and exercise therapy on pain and function of patients with knee osteoarthritis: a randomized controlled trial with 12-week follow up. Lasers in medical science 34.3 (2019): 505-516