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Overall, expired medications can be less effective, and some may even cause unwanted effects due to the breakdown of their components
That works until complexity grows: missed doses, inconsistent protein intake, and untracked nausea cause wasted refills and slower progress, translating directly into dollars lost and time spent
This is the first study of its type looking at longer-term maintenance with an oral GLP-1 after taking an injectable, said Dr
Consult a nutritionist for advice on a healthy, balanced diet containing lean proteins, nutrient-dense meals, and foods with low glycemic index
Clinical trials vs real-world results What the clinical trials show The landmark SURMOUNT-5 trial published in 2025 compared these medications directly at standard maximum doses: 1 Mounjaro (tirzepatide 15 mg) produced 20.2% average weight loss Wegovy (semaglutide 2.4 mg) produced 13.7% average weight loss The 6.5 percentage point difference was statistically significant This trial used the maximum approved doses at the time (Mounjaro 15 mg, Wegovy 2.4 mg) and lasted 72 weeks
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