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The cuproptosis-related gene PDHA1 may serve as a node linking these pathways, regulating lipid metabolism through its interaction with the PI3K-Akt-mTOR signaling pathway [123] (Figure 5)

Nitroglycerine, bosentan, and darusentan mitigate microcirculatory obstruction by dilating hepatic sinusoid

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Also interesting, no nitrosylation of GSH/GSSG was oberved in the presence of iron complexes, which seems to indicate a preferential oxygen activation chemistry by this transition metal ion

First, this study was unable to elucidate the underlying mechanism causing the poor prognosis in patients with GPX4 positive NSCLC