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IL-1 is a commonly used proinflammatory cytokine to establish in vitro model of OA [120]

Carbon monoxide (CO) levels are high in CS and CO is a known inhibitor of heme-containing enzymes such as the cytochrome P450s [30] and mitochondrial complexes [31]

Apart from endothelial cells, other components, such as pericytes, astrocytes, microglia, NG2-glia, oligodendrocytes, basement membrane, and perivascular macrophages, form and contribute to the proper functioning and integrity of the BBB

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How hyperaminoacidemia increases ER calcium released in cells from GCGR-KO mice needs further exploration