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doi: 10.1183/09031936.01.99114901 95 CarrollELBailoMReihillJACrillyALockhartJCLitherlandGJet al

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Mice not treated with vitamin A, but receiving saline in the same dosage at the same time, were used as controls

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Neurologically, ALD/AMN can manifest with highly variable phenotypes, ranging from very aggressive and rapidly fatal inflammatory CNS demyelination in young boys to a more slowly progressive adult form either with cerebral white matter inflammatory lesions, or a more indolent progressive myelopathy and peripheral neuropathy (Moser, 1997)