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Effects of oral semaglutide on cardiovascular outcomes in individuals with type 2 diabetes and established atherosclerotic cardiovascular disease and/or chronic kidney disease: Design and baseline characteristics of SOUL, a randomized trial

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As a general principle, it takes approximately five half-lives for a medication to be considered essentially eliminated from the body (representing about 97% clearance)

Different dose ranges are being tested in studies, with 12 mg weekly as the maximum dose tested so far