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Alpha-MSH's anti-inflammatory activity, mediated via the melanocortin 1 receptor (MC-1R), has been associated with its ability to modulate immune responses and influence tissue repair

168 Indeed, liver biopsies confirm that the prevalence of clinically significant fibrosis in MASLD and MASH patients is only 20.27% and 35.14%, respectively, 169 with lower proportions in patients with normal or lean body weight, 170 suggesting that antifibrotic treatment may not be necessary for a larger proportion of patients