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After assessing normality (Shapiro-Wilks tests), LME models were used to test the effect of time and the interaction of group and time with the covariates of age and sex with each participant included as a random effect on the alpha diversity metrics using the nLME package (v3.1.160)

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FIGURE 1 Semaglutide was the commonest GLP-1 agonist used (13.7%), terzipatide was used in 4.8%, while 3.3% of patients with high body mass index were on liraglutide