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Tolerability Issues and Individual Risk Factors Even in people without absolute contraindications, semaglutide causes significant gastrointestinal side effects in 1030% of users: nausea, vomiting, diarrhea, and constipation that sometimes persist despite dose escalation

Mass spectrometry analyses were performed by the Proteomics and Modomics Experimental Core (PROMEC), Norwegian University of Science and Technology, which is a member of the National Network of Advanced Proteomics Infrastructure (NAPI), Norway