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FIGURE 3 3.3 Nitazoxanide reduced inflammation in rats with MTX-hepatotoxicity A profound hepatic inflammation was observed in the MTX group, as demonstrated by significant augmentation in hepatic TNF-, IL-1, and IL-6 versus the CTRL group (Figures 4AC)

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Tamoxifen (Sigma Aldrich, T5648) was administered by intraperitoneal injection at 160 mg/kg once daily for 5 days

We next used LCMS to see if we could detect changes in fatty acid synthesis following ABHD11 inhibition in CD8 + T cells