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Furthermore, studies evaluating the histological progression of MASLD severity over time using paired liver biopsies have found a lower likelihood of fibrosis regression among active smokers (e.g., only 4% regression compared to 12% progression) [63]

That 23-pound difference represents meaningful additional risk reduction for obesity-related conditions

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When using a grace period of 60, 90 or 180 days to define treatment discontinuation, most treatment reinitiations occurred within the first year after discontinuation, but this pattern was not seen with a grace period of 365 days

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