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Adjunct Therapy : Used alongside conventional IBS management strategies, such as diet modifications or medication, to potentially improve symptom relief and digestive function

Table 3: Selected genetic causes of obesity Navigation Tips: First column and header row are frozen for easy reference Scroll horizontally and vertically to view all data Hover over rows to highlight them Use compact mode to fit more content Hover over truncated text to see full content Setmelanotide, an MC4R agonist and first-in-class treatment for hereditary obesity Setmelanotide, (Imcivree), is an MC4R agonist discovered by Ipsen SA and developed by Rhythm Pharmaceuticals that has been approved in the US since 2020 for treatment of obesity due to deficiencies of POMC, PCSK1 or LEPR confirmed by genetic testing 15 and since 2022 for syndromic obesity due to Bardet-Biedl Syndrome, a rare genetic ciliopathy 34

10.4252/wjsc.v16.i6.670 40 GarrettS

Results vary by individual A few users did not notice clear effects yet or felt outcomes were slower than expected

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