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Ex vivo rectal tumour samples more accurately reflect the dynamic tumour microenvironment, the complex architecture of the tumour, and the inherent genetic diversity between patients and therefore, this data supports metformin as a metabolic modulator in rectal tumours

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Moreover, a positive correlation between the antral length and frequency of defecation per week was found in KD with L- carnitine supplementation group denoting that an increase in antral length was associated with more frequent defecations

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