semaglutide anti inflammatory effects of once-weekly 2.4 mg on C-reactive protein in adults with overweight or obesity (STEP 1, 2, and 3): exploratory analyses of three randomised, double-blind, placebo-controlled, phase 3 trials DrLeanaWen has written extensively about

These include: Pain, redness, or swelling at the injection site Bruising or hardening of tissue (induration) Itching or warmth around the injection area Temporary discolouration of the skin These localised reactions typically resolve within 2472 hours

If sleep disturbances persist beyond the initial adjustment period (typically 48 weeks), further evaluation may be warranted to exclude other causes

That is a 6.5 percentage-point absolute gap, or roughly 47% more relative weight reduction on tirzepatide

Reduced appetite is also expected, but too little appetite can become a problem if it leads to under-eating

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